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Literature summary extracted from

  • Ayna, A.; Moody, P.
    Crystal structures of a dual coenzyme specific glyceraldehyde-3-phosphate dehydrogenase from the enteric pathogen Campylobacter jejuni (2021), J. Mol. Struct., 1242, 130820 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.59 single gene Campylobacter jejuni

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.59 purified enzyme in complex with ADP, NAD+, and NADP+, X-ray diffraction structure determination and analysis at 2.05-2.25 A resolution Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.59 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Campylobacter jejuni
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
1.2.1.59 D-glyceraldehyde 3-phosphate + phosphate + NADP+ Campylobacter jejuni
-
 3-phospho-D-glyceroyl phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.59 Campylobacter jejuni A0A1E7PFR0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.59 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Campylobacter jejuni 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 ?
1.2.1.59 D-glyceraldehyde 3-phosphate + phosphate + NADP+
-
 Campylobacter jejuni 3-phospho-D-glyceroyl phosphate + NADPH + H+
-
 ?
1.2.1.59 additional information the enzyme plays dual coenzyme specificity with NAD+ and NADP+ Campylobacter jejuni ?
-
-

Synonyms

EC Number Synonyms Comment Organism
1.2.1.59 CjGAPDH
-
 Campylobacter jejuni
1.2.1.59 GAPDH
-
 Campylobacter jejuni

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.59 additional information the enzyme plays dual coenzyme specificity with NAD+ and NADP+, binding structures analysis Campylobacter jejuni
1.2.1.59 NAD+
-
 Campylobacter jejuni
1.2.1.59 NADP+
-
 Campylobacter jejuni

General Information

EC Number General Information Comment Organism
1.2.1.59 physiological function phosphorylating glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a ubiquitous cellular enzyme that has a defined role in glycolysis and other pathways where it catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate. The enzyme complexes with ADP and might be moonlighting Campylobacter jejuni